Dynamically Driven Ligand Selectivity in Cyclic Nucleotide Binding Domains
نویسندگان
چکیده
منابع مشابه
Dynamically driven ligand selectivity in cyclic nucleotide binding domains.
One of the mechanisms that minimize the aberrant cross-talk between cAMP- and cGMP-dependent signaling pathways relies on the selectivity of cAMP binding domains (CBDs). For instance, the CBDs of two critical eukaryotic cAMP receptors, i.e. protein kinase A (PKA) and the exchange protein activated by cAMP (EPAC), are both selectively activated by cAMP. However, the mechanisms underlying their c...
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Cyclic nucleotide-gated (CNG) channels comprise four subunits and are activated by the direct binding of cyclic nucleotide to an intracellular domain on each subunit. This ligand binding domain is thought to contain a beta roll followed by two alpha helices, designated the B and C helices. To examine the quaternary structure of CNG channels and how it changes during ion channel gating, we intro...
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Since the discovery of cAMP in the 1950s and the subsequent identification of cGMP, the role of these second messengers in mediating cellular function has been a major theme of research in biology. An important aspect of this research has been the identification and characterization of cyclic nucleotide receptors. For more than two decades, the bacterial CAMP-regulated catabolite gene activator...
متن کاملStructural snapshot of cyclic nucleotide binding domains from cyclic nucleotide-sensitive ion channels.
Cyclic nucleotide-binding domains (CNBDs) that are present in various channel proteins play crucial roles in signal amplification cascades. Although atomic resolution structures of some of those CNBDs are available, the detailed mechanism by which they confer cyclic nucleotide-binding to the ion channel pore remains poorly understood. In this review, we describe structural insights about cyclic...
متن کاملDeterminants of ligand selectivity in a cyclic nucleotide–regulated potassium channel
Cyclic nucleotide-binding (CNB) domains regulate the activity of channels, kinases, exchange factors, and transcription factors. These proteins are highly variable in their ligand selectivity; some are highly selective for either cAMP or cGMP, whereas others are not. Several molecular determinants of ligand selectivity in CNB domains have been defined, but these do not provide a complete view o...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m109.011700